On a fresh Debian Jessie I kept getting every couple of minutes this error:
do_IRQ: No irq handler for vector (irq -1)
A suggested solution is to add "pci=nomsi,noaer" in /etc/default/grub at GRUB_CMDLINE_LINUX
However, noaer refers to PCIE Advanced Error Reporting and I don't want only to hide the mess, I want to fix it (if possible).
Only adding pci=nomsi seems to do the trick so far.
Also don't forget to do a update-grub after you edit /etc/default/grub.